- Bentrio® meets primary efficacy endpoint in NASAR clinical trial in seasonal allergic rhinitis
- Clinically relevant and statistically significant improvement in Total Nasal Symptom Score over saline nasal spray control (p = 0.012)
- Bentrio efficacy and tolerability rated as "good" or "very good" by 63.5% and 73.5% of study participants
- NASAR concludes Altamira's clinical development program for Bentrio in allergic rhinitis
HAMILTON, BERMUDA / ACCESSWIRE / May 24, 2023 / Altamira Therapeutics Ltd. (Nasdaq:CYTO), a company dedicated to developing therapeutics that address important unmet medical needs, today announced positive and statistically significant top-line results from the randomized controlled NASAR clinical trial evaluating its Bentrio nasal spray in patients with seasonal allergic rhinitis (SAR). Bentrio nasal spray is formulated as a drug-free and preservative-free gel emulsion designed to help protect against airborne allergens such as pollen or house dust mites.
The NASAR trial enrolled 100 SAR patients in Australia who were randomized at a 1:1 ratio to receive either Bentrio or saline nasal spray for two weeks via self-administration three times per day, or as needed. For eligibility, patients had to have a baseline reflective Total Nasal Symptom Score (rTNSS) of at least 5 points out of 12, referring to the worst level of nasal congestion, sneezing, nasal itching, and rhinorrhea (runny nose) within the past 24 hours averaged over a one-week treatment-free run-in period. The primary efficacy endpoint was defined as the difference in the average rTNSS over the subsequent 2-week treatment period between Bentrio and saline nasal spray, the current standard of care in drug-free SAR management. The change in mean rTNSS over two weeks is generally accepted as a primary efficacy endpoint for SAR trials and is also recommended by the FDA.
Graph above compares reduction in mean reflective Total Nasal Symptom Score (rTNSS) with Bentrio vs. saline nasal spray control over two weeks of treatment from baseline
The rTNSS decreased in the Bentrio group from 6.9 points in the pre-treatment period to an average of 5.0 points over the 14-day treatment period (i.e. -1.9 points), while the saline spray group showed a decrease from 6.9 to 6.2 points (i.e. -0.8 points) (see ‘Mean rTNSS' graph). The reduction in nasal symptoms conferred by Bentrio was thus 2.5 times larger than with saline nasal spray. The difference in rTNSS reduction of 1.1 points in favor of Bentrio was statistically significant in the ANCOVA model (LSmeans; p = 0.012; 95% confidence interval -2.0 to -0.3), and the study thus met the primary efficacy endpoint.
Graph above compares patient rating of treatment efficacy with Bentrio vs. saline nasal spray control after two weeks of treatment
The treatment effect shown with Bentrio was well above the minimal clinically important difference of 0.28 points. 63.3% of Bentrio-treated study participants rated treatment efficacy as either good or very good vs. 29.2% of saline-treated participants (see ‘Patient Rating' graph). Among the latter, 45.8% reported efficacy as poor vs. only 8.2% in the Bentrio group. 73.5% of Bentrio-treated study participants rated tolerability of the treatment as either good or very good vs. 85.5% of saline-treated participants. Among the latter, 10.4% reported tolerability as poor vs. only 6.1% in the Bentrio group.
"We are thrilled with the strong outcomes from the NASAR trial, which we obtained under real-life conditions during the allergy season in Australia," commented Thomas Meyer, Altamira Therapeutics' founder, Chairman, and CEO. "The large magnitude of the reduction of nasal symptoms demonstrates that effective protection against seasonal allergic rhinitis is very well possible with a drug-free treatment. There are many patients who do not respond well to medicated nasal sprays either for lack of efficacy or due to tolerability issues with preservatives or other ingredients. I would like to extend my sincere appreciation to all the patients and investigators involved in the NASAR trial who helped us to reach this important clinical milestone.
"Further, the NASAR results show for Bentrio a statistically significant and clinically highly relevant improvement in efficacy over the current standard of care saline nasal spray treatment," Mr. Meyer added. "Whereas a saline nasal spray aims to rinse out allergen particles, Bentrio forms a thin protective layer which prevents contact of those particles with the nasal mucosa and helps to remove them through natural mucociliary clearance. As already demonstrated in a previous trial, Bentrio stays for about 3.5 hours within the nasal cavity where it can exert its protective effects. In contrast, saline spray is present for only about one hour and provides narrower distribution and less coverage within the nasal cavity.
"With the completion of the NASAR trial, Altamira has concluded its clinical development of Bentrio in allergic rhinitis management. In 2023, the US sales of over-the-counter allergy remedies are estimated to reach close to $4 billion which represents a major opportunity in the non-medicated, preservative-free treatments category. Together with its marketing and distribution partners, Altamira is looking forward to making Bentrio available as an effective and safe treatment option to help patients deal with the daily burden and discomfort associated with allergic rhinitis."
Bentrio is an OTC drug-free nasal spray for personal protection against airborne allergens and, where approved, against airborne viruses. Upon application into the nose, Bentrio forms a protective gel layer on the nasal mucosa. This thin film is designed to prevent the contact of allergens (or virus particles) with cells; in addition, the composition serves to bind such particles and help with their discharge. Together, this is designed to promote alleviation of allergic symptoms (or mitigate upper respiratory tract viral infections). For more info, visit: https://www.aurismedical.com/legacy-programs/bentrio
About Altamira Therapeutics
Altamira Therapeutics (Nasdaq:CYTO) is dedicated to developing and commercializing RNA delivery technology for extrahepatic targets (OligoPhore™ / SemaPhore™ platforms). The Company currently has two flagship siRNA programs in preclinical development beyond in vivo proof of concept: AM-401 for KRAS driven cancer and AM-411 for rheumatoid arthritis. The versatile delivery platform is also suited for mRNA and other types of RNA therapeutics and is planned to be leveraged via out-licensing to pharma or biotech companies. In addition, Altamira is in the process of divesting and/or out-licensing its legacy assets in allergology and viral infection (Bentrio® OTC nasal spray; commercial) and inner ear therapeutics (AM-125 nasal spray for vertigo; post Phase 2; Keyzilen® and Sonsuvi® for tinnitus and hearing loss; Phase 3). Founded in 2003, Altamira is headquartered in Hamilton, Bermuda, with its main operations in Basel, Switzerland. For more information, visit: https://altamiratherapeutics.com/
This press release may contain statements that constitute "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Forward-looking statements are statements other than historical facts and may include statements that address future operating, financial or business performance or Altamira Therapeutics' strategies or expectations. In some cases, you can identify these statements by forward-looking words such as "may", "might", "will", "should", "expects", "plans", "anticipates", "believes", "estimates", "predicts", "projects", "potential", "outlook" or "continue", or the negative of these terms or other comparable terminology. Forward-looking statements are based on management's current expectations and beliefs and involve significant risks and uncertainties that could cause actual results, developments and business decisions to differ materially from those contemplated by these statements. These risks and uncertainties include, but are not limited to, the success of the continued commercialization of Bentrio and success of strategic transactions, including licensing or partnering, with respect to Bentrio or any other legacy assets, Altamira Therapeutics' need for and ability to raise substantial additional funding to continue the development of its product candidates, the timing and conduct of clinical trials of Altamira Therapeutics' product candidates, the clinical utility of Altamira Therapeutics' product candidates, the timing or likelihood of regulatory filings and approvals, Altamira Therapeutics' intellectual property position and Altamira Therapeutics' financial position, including the impact of any future acquisitions, dispositions, partnerships, license transactions or changes to Altamira Therapeutics' capital structure, including future securities offerings. These risks and uncertainties also include, but are not limited to, those described under the caption "Risk Factors" in Altamira Therapeutics' Annual Report on Form 20-F for the year ended December 31, 2022, and in Altamira Therapeutics' other filings with the SEC, which are available free of charge on the Securities Exchange Commission's website at: www.sec.gov. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those indicated. All forward-looking statements and all subsequent written and oral forward-looking statements attributable to Altamira Therapeutics or to persons acting on behalf of Altamira Therapeutics are expressly qualified in their entirety by reference to these risks and uncertainties. You should not place undue reliance on forward-looking statements. Forward-looking statements speak only as of the date they are made, and Altamira Therapeutics does not undertake any obligation to update them in light of new information, future developments or otherwise, except as may be required under applicable law.
SOURCE: Altamira Therapeutics Ltd.
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How many stocks should I own with $100 K? ›
A good range for how many stocks to own is 15 to 20. You can keep adding to your holdings and also invest in other types of assets such as bonds, REITs, and ETFs. The key is to conduct the necessary research on each investment to make sure you know what you are buying and why.How many stocks should I own with 20k? ›
If your portfolio is less than $20,000 hold no more than 3 stocks. And the publication encourages investors to have no more than 5 stocks even if you are investing up to $200,000. Portfolios of up to $1,000,000 might have up to ten positions but no more.What is stock market answers? ›
Definition: It is a place where shares of pubic listed companies are traded. The primary market is where companies float shares to the general public in an initial public offering (IPO) to raise capital.How many stocks should I own as a beginner? ›
Most experts tell beginners that if you're going to invest in individual stocks, you should ultimately try to have at least 10 to 15 different stocks in your portfolio to properly diversify your holdings.How to turn $100 K into $1 million in 5 years? ›
Consider investing in rental properties or real estate investment trusts (REIT). The real estate market is a fertile setting for a $100k investment to yield $1 million. And it's possible for this to happen between 5 to 10 years. You can achieve this if you continue to add new properties to your portfolio.How to invest $100 000 to make $1 million? ›
Invest $400 per month for 20 years
If you're earning a 10% average annual return and investing $400 per month, you'd be able to go from $100,000 to $1 million in savings in just over 20 years. Again, if your actual average returns are higher or lower than 10% per year, that will affect your timeline.
"the investor should never have less than 25% or more than 75% of his funds in common stocks."Is owning 30 stocks too much? ›
Assuming you do go down the road of picking individual stocks, you'll also want to make sure you hold enough of them so as not to concentrate too much of your wealth in any one company or industry. Usually this means holding somewhere between 20 and 30 stocks unless your portfolio is very small.What is the 20% rule in stocks? ›
In investing, the 80-20 rule generally holds that 20% of the holdings in a portfolio are responsible for 80% of the portfolio's growth. On the flip side, 20% of a portfolio's holdings could be responsible for 80% of its losses.How can I double $5000 dollars? ›
- Start a Side Hustle. Perhaps the most common method of making more money is starting a side hustle. ...
- Invest in Stocks and Bonds. ...
- Day Trade. ...
- Save More Money. ...
- Buy and Resell Items on Amazon and eBay. ...
- Build an eCommerce Business. ...
- Sell Your Stuff. ...
- Earn cashback When You Shop.
Is the stock market math? ›
And the answer is: They do it with MATH! Digging deeper, in this process, data is bought from the stock market and is analysed. It is then on the basis of this stock market data that they come up with the possible percentage of odds (say, 65% or 75% and so on) with regard to the movements of stock prices.Is stock market easy? ›
As it turns out, investing isn't as hard — or complex — as it might seem. That's because there are plenty of tools available to help you. One of the best is stock mutual funds, which are an easy and low-cost way for beginners to invest in the stock market.How much money do I need to invest to make $1000 a month? ›
Reinvest Your Payments
The truth is that most investors won't have the money to generate $1,000 per month in dividends; not at first, anyway. Even if you find a market-beating series of investments that average 3% annual yield, you would still need $400,000 in up-front capital to hit your targets.
Through fractional share investing, $500 can go a long way towards building a diversified portfolio of stocks. Previously, if you wanted to buy a larger company's shares, ordinarily that would cost hundreds to thousands of dollars per share.What type of stock is best for beginners? ›
- Amazon (NASDAQ: AMZN)
- Alphabet (NASDAQ: GOOG)
- Apple (NASDAQ: AAPL)
- Costco (NASDAQ: COST)
- Disney (NYSE: DIS)
- Meta (NASDAQ: META)
- Mastercard (NYSE: MA)
- Microsoft (NASDAQ: MSFT)
Based on the median costs of living in most parts of America, $5 million is more than enough for a very comfortable retirement. Based on average market returns, $5 million can support many households indefinitely.How to make $10 million in 10 years? ›
- Keep it simple.
- Invest $540,000 per year, every year, for 10 years.
- Invest for Growth.
- Invest with Conviction.
- Use market volatility to your advantage.
- Get started right away. On your own or with a professional advisor by your side.
Assuming you will need $40,000 per year to cover your basic living expenses, your $1 million would last for 25 years if there was no inflation. However, if inflation averaged 3% per year, your $1 million would only last for 20 years.Is $500,000 a big inheritance? ›
$500,000 is a big inheritance. It could have a significant impact on a person's financial situation, depending on how it is managed and utilized. As you can see here, there are many complex, moving parts involving several financial disciplines.How to turn $1 million into $2 million? ›
To go from $1 million to $2 million likewise requires 100% growth, but the next million after that requires only 50% growth (and then 33% and so on).
How much money do I need to retire? ›
A good rule of thumb is to save enough to cover 80% of your pre-retirement income. You'll need to account for inflation and how it affects your purchasing power down the line. Retirement needs are highly individualized based on your desired lifestyle.What is the 7% rule in stocks? ›
To make money in stocks, you must protect the money you have. Live to invest another day by following this simple rule: Always sell a stock it if falls 7%-8% below what you paid for it. No questions asked. This basic principle helps you cap your potential downside.What is the 70% rule in stocks? ›
The rule of 70 is used to determine the number of years it takes for a variable to double by dividing the number 70 by the variable's growth rate. The rule of 70 is generally used to determine how long it would take for an investment to double given the annual rate of return.What is the 4% stock rule? ›
What is the 4% rule for retirement? The 4% rule states that you should be able to comfortably live off of 4% of your money in investments in your first year of retirement, then slightly increase or decrease that amount to account for inflation each subsequent year.Is it OK to be 100% in stocks? ›
In theory, young people investing for retirement should absolutely have 100% of their portfolio invested in equities. The biggest risk in the stock market is a crash which brings lower prices. Your best-case scenario as a young saver/investor is that you get to put more savings to work at lower prices.Can the average person get rich off stocks? ›
Investing in the stock market is one of the best way to get rich, if not the best ways to do so -- as long as you understand that it will typically take awhile. Stocks that increase in value 1,000%, or even 10,000%, generally take many years to do so.Is 100% stocks a bad idea? ›
The main argument advanced by proponents of a 100% equities strategy is simple and straightforward: In the long run, equities outperform bonds and cash; therefore, allocating your entire portfolio to stocks will maximize your returns.What is the 80% rule in stock market? ›
A futures trading technique which operates under the assumption that if a market opens outside its value area. The range is derived from one standard deviation on either side of the mean which is roughly 70%.What is the 5 dollar stock rule? ›
Margin Rules for Low Priced Stocks: Overview
Place Trade does not have a special rule regarding stocks that trade below $5. Although other brokerage firms may have a house rule regarding stocks trading below $5, PT does not employ such a rule.
It dates back to 1943 and states that commissions, markups, and markdowns of more than 5% are prohibited on standard trades, including over-the-counter and stock exchange listings, cash sales, and riskless transactions. Financial Industry Regulatory Authority (FINRA).
How to flip $10,000 dollars fast? ›
- Real estate investing. One of the more secure options is investing in real estate. ...
- Product and website flipping. ...
- Invest in index funds. ...
- Invest in mutual funds or EFTs. ...
- Invest in dividend stocks. ...
- Peer-to-peer lending (P2P) ...
- Invest in cryptocurrencies. ...
- Buy an established business.
- Start Dropshipping with Shopify. ...
- Offer Freelance Writing Services. ...
- Start a Bookkeeping Business. ...
- Open a Custom Pins Shop Online. ...
- Start Affiliate Marketing with Clickbank. ...
- Start a Blog. ...
- Sell T-Shirts through Tee Spring. ...
- Start a Web Development Business.
- Sell Your Car. If you own a car that's paid off, you could sell it and make a significant chunk of money quickly. ...
- Sell Unwanted Jewelry. ...
- Sell Stuff You Don't Need. ...
- Start a Trash Cleanup Business. ...
- Rent Out Your Camper or RV. ...
- Rent Out Your House. ...
- Rent Out Your Car or Truck. ...
- Rent Out Storage Space.
The average investor may not have a very good chance of beating the market. Regular investors may be able to achieve better risk-adjusted returns by focusing on losing less. Consider using low-cost platforms, creating a portfolio with a purpose, and beware of headline risk.Do stock traders need to be good at math? ›
Becoming a trader requires a background in math, engineering, or hard science, rather than just finance or business. Traders need research and analytical skills to monitor broad economic factors and day-to-day chart patterns that impact financial markets.Is stock market difficult? ›
Though there are a number of people who have made it big in stock trading, trading in equities is not at all easy. One need to have discipline and patience and it also requires research with a thorough understanding of the markets.Can you self learn stocks? ›
It's possible to learn stock trading theory by reading a book, but gaining the practical knowledge, skills, and confidence to trade with your own money requires more extensive training with real-time support.Why do beginners lose money in stock market? ›
Lack of patience
Patience is the key to success in the stock market. However, most people who lose money in the stock market do not have patience. Although many times, beginners are able to find good stocks, they aren't able to get good profits from them.
|Annual Salary||Monthly Pay|
Small amounts will add up over time and compounding interest will help your money grow. $20 per week may not seem like much, but it's more than $1,000 per year. Saving this much year after year can make a substantial difference as it can help keep your financial goal on your mind and keep you motivated.
How much will I have if I invest $500 a month for 10 years? ›
If you invested $500 a month for 10 years and earned a 4% rate of return, you'd have $73,625 today. If you invested $500 a month for 10 years and earned a 6% rate of return, you'd have $81,940 today.How much do I need to make a day to make 10k a month? ›
With an average of 30 days each month, you'll need to make about $333 per day, every day, to reach your goal. Now that you've got that number sorted, you can start asking yourself how you'll make it happen.Is $20 dollars enough to invest in stocks? ›
In the past, you were out of luck if you did not have enough money to buy a share of stock. But nowadays, you can find brokerages that will let you buy fractional shares. So, investing $20 in stocks is possible even if you don't have enough money to buy a share.Is $30 dollars enough to invest in stocks? ›
Even if you have only $30, making investments can be relatively easy. For less than the cost of a few pizzas, you can even own stocks. Anyone can buy a share of stock, as long as you have a brokerage account.Is $100 too little to invest? ›
Investing can change your life for the better. But many people mistakenly think that unless they've got thousands of dollars lying around, there's no good place to put their money. The good news is that's simply not the case. You can start investing with $100 or even less.What is the safest stock to buy? ›
- The Home Depot, Inc. (NYSE:HD)
- Costco Wholesale Corporation (NASDAQ:COST)
- Walmart Inc. (NYSE:WMT)
- AbbVie Inc. (NYSE:ABBV)
- The Procter & Gamble Company (NYSE:PG)
- Pfizer Inc. (NYSE:PFE)
- Merck & Co., Inc. (NYSE:MRK)
- Exxon Mobil Corporation (NYSE:XOM)
Coke remains an attractive long-term investment idea based on resilient topline growth, high margins, and consistent excess investment returns for more than 20 years. That said, the stock is trading at a 10% premium to our $58 fair value estimate, and we'd wait for a better entry point.What stocks to buy for next 10 years? ›
|Growth stock||Year-to-date return (as of May 10 close)|
|Apple Inc. (ticker: AAPL)||33.8%|
|DexCom Inc. (DXCM)||8.2%|
|Fortinet Inc. (FTNT)||37.1%|
|Tesla Inc. (TSLA)||36.8%|
How much interest can $100,000 earn in a year? If you put $100,000 in CDs, high-yield savings or a money market account for a year, you could earn anywhere from $3,000 to $5,000 based on current interest rates.What should I invest in with $100 K? ›
- Index Funds, Mutual Funds and ETFs.
- Individual Company Stocks.
- Real Estate.
- Savings Accounts, MMAs and CDs.
- Pay Down Your Debt.
- Create an Emergency Fund.
- Account for the Capital Gains Tax.
- Employ Diversification in Your Portfolio.
How much monthly income will 100K generate? ›
A $100,000 annuity would pay you approximately $508 each month for the rest of your life if you purchased the annuity at age 60 and began taking payments immediately.How much will $100 000 grow in 30 years? ›
If you can achieve an 8% compounding annual rate of return on $100,000, it will take 30 years for that capital to grow into $1 million.How much interest on $1 million dollars per year? ›
With $1,000,000 invested, you will get $46,700 per year in interest.Can I live off interest on a million dollars? ›
Once you have $1 million in assets, you can look seriously at living entirely off the returns of a portfolio. After all, the S&P 500 alone averages 10% returns per year. Setting aside taxes and down-year investment portfolio management, a $1 million index fund could provide $100,000 annually.How much interest does $3 million dollars earn per year? ›
A typical stock dividend portfolio will earn between 2% and 5% in dividends each year. Additionally, the portfolio may grow over time to provide higher dividends and capital gains in the future. On a $3 million portfolio, you can expect to receive $60,000 to $150,000 per year. Real estate investment trust (REIT).How much do 40 year olds have saved? ›
As you can see, the average savings by 40 is higher than $48,000 but likely lower than $148,000. However, it's worth noting that just because that's the average, that amount may not be what you might want to consider having saved.How can I double my money without risk? ›
- Take Advantage of 401(k) Matching.
- Invest in Value and Growth Stocks.
- Increase Your Contributions.
- Consider Alternative Investments.
- Be Patient.
- Wholesaling properties.
- Fixing and flipping homes.
- Buying and holding rental properties.
- Investing in mortgage debt.
- Private money lending to other investors.
- Stocks, REITs and partnerships.
The quick answer is “yes”! With some planning, you can retire at 60 with $500k. Remember, however, that your lifestyle will significantly affect how long your savings will last.Can I retire at 64 with $600,000? ›
If you manage to stay healthy and never need long-term care then $600,000 could be enough to sustain you in retirement. On the other hand, if you need long-term care in a nursing facility that could take a large bite out of your savings.
How much does a $300000 annuity pay per month? ›
How Much Does A $300,000 Annuity Pay Per Month? A $300,000 annuity would pay you approximately $1,314 each month for the rest of your life if you purchased the annuity at age 60 and began taking payments immediately.How to save $1 million dollars in 5 years? ›
- Capitalize on Compound Interest. ...
- Leverage Your Job. ...
- Establish Daily, Weekly and Monthly Savings Goals. ...
- Identify Ways to Increase Your Income. ...
- Find Simple Investments to Grow Your Money. ...
- Cut Expenses.
STEP 1: Commit to investing regularly.
Specifically, to accumulate $10,000,000 in 10 years according to the assumptions above; Invest a minimum $540,000 per year. Realistically, this is doable if your income exceeds > $1 million+ per year and you're serious about delaying gratification in the name of financial success.
ノ 12. How long will it take $4,000 to grow to $9,000 if it is invested at 7% compounded monthly? 11.62 yrs.